Farming Infected Blood in Resident Evil Requiem is one of the smartest ways to stay ahead in the game as Grace Ashcroft. Without enough of it, you’ll quickly run dry on ammo and healing items while the infected keep coming. I’ve played through the Rhodes Hill Chronic Care Center multiple times now, and I can tell you that once you master the Blood Collector, resource management becomes way less stressful.
In this article, you’ll learn the exact steps to grab the RE9 Blood Collector, where to find reliable sources of Infected Blood, the best farming methods, and much more.
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Acquiring the Resident Evil Requiem Blood Collector Early
The Blood Collector becomes available once you reach the East Wing of the Rhodes Hill Chronic Care Center. Head straight to the Blood Lab and you’ll spot it on a desk alongside the first Blood Specimen (Denatured). Pick it up immediately.
From that moment on, the device lets you harvest Infected Blood from pretty much any visible red mess—zombie corpses, floor pools, buckets, bathtubs, you name it. The game even starts marking these sources on your map, which makes backtracking surprisingly efficient. I remember feeling a huge relief the first time I equipped it because suddenly crafting wasn’t a distant dream anymore.
Understanding Where Infected Blood Comes From in RE9
RE9 Infected Blood drops in three main ways, and knowing the yields helps you prioritize:
- Zombie corpses: Regular zombies give 20-30 units. Shooting them in the head or legs leaves behind bigger blood spatters for better results.
- Environmental sources: Blood buckets often net up to 50 units each, while pools on the floor or in bathtubs give smaller but steady amounts.
- Transfusion bags: These are the real prize. You’ll find them on certain zombies carrying IV poles. Defeating them can drop bags worth 50-70 units or more, depending on the area.
I always make it a habit to clear rooms thoroughly once I have the collector because those environmental sources add up fast, especially in the kitchen or pantry areas.
Best Ways to Farm Infected Blood in Resident Evil Requiem Efficiently
The key to farming Infected Blood in Resident Evil Requiem isn’t just running around killing everything—it’s smart repetition. Here’s what has worked best for me across playthroughs:
- Backtrack with map markers: After you get the collector, previously visited areas light up with collectible icons. Swing back through the East Wing and West Wing whenever you’re low. It’s low-risk and surprisingly productive.
- Target high-yield spots: The kitchen has multiple buckets and pools. The pantry nearby offers another couple of easy grabs. Clear the area, collect everything, then move on.
- The reload farming method: This is the real game-changer for big hauls and the Bloodlust challenge. Find a reliable transfusion bag (one early example is the blind zombie in the waiting room). Kill the zombie, grab the bag, but don’t use it yet. Make a manual save at a nearby typewriter. Use or craft with the bag to fill your collector, then reload the save. The bag (or blood sources) reappears, and your total collected blood still counts toward achievements. Repeat as needed. I’ve used this in the basement near the grinder slide and in later areas with bigger bags to rack up hundreds of units quickly without burning resources.
- Focus on vascular hits: When fighting, prioritize headshots and leg shots on zombies. It increases the blood left behind and makes each encounter more profitable.
- Combine with crafting runs: Empty your collector by crafting ammo or injectors, then go farm again. This keeps your inventory manageable while steadily progressing toward the 5,000 microsamples needed for the Bloodlust trophy.
Upgrading the Blood Collector Capacity
Your RE9 Blood Collector starts with a 100-unit cap, which is fine for basic handgun ammo but falls short for bigger recipes like Stabilizers or Steroids that need 120+ units at once.
To fix this, collect six Antique Coins and head to the Parlor in the West Wing. Use them on the coin cabinet to buy the Override Manual. This will boost capacity to 150 units and let you craft anything the game offers.
After winning the RE9, you will be able to unlock the Matsuoka Master Manual from the Special Contents menu for 1,000 Challenge Points. It gives another +50 capacity on your next playthrough, pushing you up to 200. I always grab the first upgrade as soon as possible because it removes so much back-and-forth frustration.
Making the Most of Your Infected Blood Through Crafting
Once you have the blood, take Blood Specimens to the Laser Microscope in the Blood Lab for analysis. Solving the simple helix mini-game unlocks new recipes. From there, open your inventory, switch to the Crafting tab, and combine Infected Blood with scrap, rare metals, or herbs to make:
- Handgun ammo
- Hemolytic Injectors for healing
- Stabilizers and Steroids for permanent upgrades
Additionally, the Bloodlust challenge rewards 10,000 CP for collecting 5,000 microsamples, which is perfect for unlocking extras like infinite ammo on replay. The reload method makes this feel rewarding instead of tedious.
Conclusion: Infected Blood Farming in Resident Evil Requiem
Farming Infected Blood in Resident Evil Requiem doesn’t have to be a chore. Grab the Blood Collector early, learn the high-yield sources, master the save-reload loop for transfusion bags, and upgrade your capacity as soon as you can. What started as a confusing new mechanic quickly became one of my favorite parts of playing as Grace. With a bit of practice, you’ll be turning the horror against itself in no time.
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